The proteins produced by partial decomposition of microorganisms are often recognized by the body's immune system as foreign antigens trigger production of antibodies that can be detected in the blood. Such antibodies are proteins in the cell wall (outer membrane) or flagella of the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae (Baker's or brewer's yeast) that are found in Crohn's disease. The stimulation of the immune system by these proteins may also confuse the body into believing it is necessary to continue fighting an ongoing battle against an invader. The result of the ongoing intestinal inflammation and immune stimulation associated with leaky gut often begins a self-perpetuating process whereby the body attacks or injures himself long after infection or invasion of microorganisms has been destroyed. This is the autoimmunity. The result of self-harm may occur locally in the gut or in distant parts of the body more typically in the brain or nerves, skin, joints and glands like the pancreas and thyroid.
increased permeability of the intestine due to loss preservation of the normal barrier of the intestinal tight junctions may predispose to further injury of microorganisms and / or protein foods. This vicious cycle of the intestinal lesion in combination with altered intestinal flora, leaky gut, food sensitivity, intestinal inflammation and intestinal leakage is greater being recognized as one of the critical links to various bowel inflammation, neurological and autoimmune diseases.
Probiotics are becoming again is useful in many conditions. By replacing depleted microorganisms good and the restoration of probiotics in the gut micro ecology have shown normal have a beneficial effect on many gastrointestinal diseases. Probiotics are commonly used consist of one or more strains of live bacteria Lactobacillus different acidophilus and Bifidobacterium species. The most studied commercially available probiotic VSL # 3 is that contains billions of live bacteria of different species. However, the yeast Saccharomyces boulardii has also proved beneficial in various intestinal diseases. Several recent studies highlight the importance of intestinal flora in ulcerative, Crohn's disease, irritable bowel syndrome, antibiotic-associated diarrhea (Clostridium difficile infection), traveler's diarrhea, and celiac disease.
Tjellström et al of Sweden took note of short chain fatty acids (SCFA), one of the healthy products of normal microflora in the intestine, was altered in children with celiac disease. Altered levels of SCFAs are believed to be associated with altered nutrition on intestinal lining cells, and the lack of protection against certain disease-causing bacteria. What he proposes is that they altered the gut flora in the intestinal lining high renewal cellular and lots of undigested proteins is presented to the intestinal flora resulting in celiac disease development in genetically predisposed especially in the context of another event, like a virus infection. They concluded "our findings may reflect an abnormal intestinal flora in CD, which can be a new intriguing piece of the puzzle … "VSL # 3 probiotic added to wheat flour has also been shown to be able to break the toxic protein gliadin in celiac disease.
Bacterial antigens (proteins) of live bacteria were shown by Sydora et al intestinal permeability increase and put ongoing injury to the intestines resulting in inflammation or activation of immune defenses against infection process. It was demonstrated in a mouse model that while both dead and live forms of some bacteria can cause increased intestinal permeability or leaky gut caused only live bacterial inflammation intestinal. While the focus of his study was how the bacteria may play a role in the development of inflammatory bowel diseases (eg, colitis and disease Crohn's disease), your results may add to the tracks the role of microorganisms in the gut to leak that predisposes to a variety of gastrointestinal disorders. Also lends credence to the clinical observation, research data and patient experience that several antibiotics and / or probiotic regimens are often beneficial for many patients with gastrointestinal conditions.
Probiotics contain live bacteria or yeasts that have beneficial effects health. They restore the balance of microorganisms in the gut. They produce natural antibiotics to prevent overgrowth of bad bacteria in the gut. Probiotic bacteria produce food, in particular short-chain fatty acids that are healthy foods to the intestinal lining cells that maintain barrrier thus preventing intestinal leaky gut. Probiotic bacteria can break down toxic protein gliadin as food, while the bad bacteria can act in concert with the gliadin of injuring the bowel. Probiotic yeast Saccharomyces boulardii also appears to help regulate the immune system in the intestine. Probiotics help win the war against terrorism in the intestine.
References:
intestinal microflora associated characteristics in children with celiac disease. Tjellström, B, et al. American Journal of Gastroenterology 2005, 100, 2784-2788
Bacterial antigens alone can influence intestinal barrier integrity, but live bacteria are necessary for the initiation of intestinal inflammation and injury. Sydora, B. et al Inflammatory Bowel Disease 2006, 12:429-436.
VSL # 3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Disease. De Angelis, M. et al. Biochim Biophys Act 2006; 1762 (1): 80-93
Probiotics prevent bacterial translocation and improve barrier function in rats following chronic psychological stress. Zariee, M. et casing to 206; 55:1553-1560.
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The Food Doc, Dr. Scot Lewey, is an expert medical doctor specializing in digestive diseases and food related illness, especially food allergies, celiac disease and colitis. Dr. Lewey’s expert reputation as the Food Doc is established by a foundation of formal training in internal medicine, pediatrics, and gastroenterology (diseases of the digestive tract), his personal and family experience with gluten and milk sensitivity, and over two decades as a practicing physician, clinical researcher, author and speaker. Access this expert knowledge online today at http://www.thefooddoc.com
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